PD04-08 URINARY INCONTINENCE AND QUALITY OF LIFE: A PRINCIPAL COMPONENT ANALYSIS OF THE STANFORD WSDM OBSERVATIONAL LOWER URINARY TRACT SYMPTOM (LUTS) COHORT

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Male Incontinence: Therapy I (PD04)1 Sep 2021PD04-08 URINARY INCONTINENCE AND QUALITY OF LIFE: A PRINCIPAL COMPONENT ANALYSIS OF THE STANFORD WSDM OBSERVATIONAL LOWER URINARY TRACT SYMPTOM (LUTS) COHORT Chen Shenhar, Abdelrahman S. Abdalla, Stefanie van Uem, Ashu Mohammad, Bertha H. Chen, Elizabeth A. Kidd, and Amy D. Dobberfuhl Chen ShenharChen Shenhar More articles by this author , Abdelrahman S. AbdallaAbdelrahman S. Abdalla More articles by this author , Stefanie van UemStefanie van Uem More articles by this author , Ashu MohammadAshu Mohammad More articles by this author , Bertha H. ChenBertha H. Chen More articles by this author , Elizabeth A. KiddElizabeth A. Kidd More articles by this author , and Amy D. DobberfuhlAmy D. Dobberfuhl More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001968.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Urinary incontinence (UI) is included in the ICIQ FLUTS / MLUTS questionnaires, but not in the AUASI. Our aim was to study the effect of UI on quality of life (QOL) in females and males using principal component analysis. METHODS: Subjects were prospectively enrolled into the Stanford WSDM observational LUTS cohort from a functional urology clinic and answered questionnaires. Data were analyzed in SAS using principal component analysis (PCA) to identify LUTS domain groups. Eigenvalues over 1 were retained. Multivariate logistic regression was performed using the gender specific principal components to ascertain the effect of LUTS domains on the outcome AUASI QOL. RESULTS: A total of 304 patients (178 female, 126 male) were enrolled. Mean age was 58±17 years. 540 clinic visits occurred between May 2019 and November 2020. Response rates were 93% (500/540) for AUASI, and 91% (490/540) for ICIQ. For the AUASI, unsupervised PCA identified the principal components as either voiding phase or storage dysfunction. While for the ICIQ questionnaires, unsupervised PCA identified voiding, storage and incontinence as the dominant LUTS domains. In females, maximum likelihood estimates for the effect of LUTS on QOL were significant for all components of the ICIQ FLUTS (incontinence p<0.0001, voiding p<0.0001, storage p=0.008) and for the storage component of the AUASI (p=0.004). In males, maximum likelihood estimates were significant for the incontinence (p=0.024) and storage (p=0.027) components of the ICIQ MLUTS, as well as the voiding (p=0.018) and storage (p=0.006) components of the AUASI. Given the significance of UI on QOL, which is not ascertained by the AUASI, predicted probabilities of QOL were plotted using the incontinence PCA component scores, while holding the other component domains constant. This identified the inflection point for significant UI as AUASI QOL 5 or 6 in women, whereas UI in men was adversely associated as a driving component of worse QOL for men reporting AUASI QOL 4, 5 or 6 (Figure 1). CONCLUSIONS: UI is a significant driver of QOL and potentially under ascertained in men given the absence of a UI specific item in the AUASI. Men need to be queried for the presence of UI, as UI appears to be a significant driver of worse QOL. Source of Funding: NIH 1L30DK115056-01, Stanford Women's Health and Sex Differences in Medicine (WSDM) Seed Grant © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e52-e53 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Chen Shenhar More articles by this author Abdelrahman S. Abdalla More articles by this author Stefanie van Uem More articles by this author Ashu Mohammad More articles by this author Bertha H. Chen More articles by this author Elizabeth A. Kidd More articles by this author Amy D. Dobberfuhl More articles by this author Expand All Advertisement Loading ...