PD02-09 WOUND HEALING PROCESS IN ELDERLY BEAGLES AFTER TRANSURETHRAL VAPORIZATION OF THE PROSTATE WITH A NOVEL 450 NM 200 W LASER

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD02-09 WOUND HEALING PROCESS IN ELDERLY BEAGLES AFTER TRANSURETHRAL VAPORIZATION OF THE PROSTATE WITH A NOVEL 450 NM 200 W LASER Xiaofeng Xu, Guoxiong Liu, Dali Jiang, Hengtong Fan, Zejun Ren, Bing Yang, Liyue Mu, Dalin He, and Lin Yang Xiaofeng XuXiaofeng Xu More articles by this author , Guoxiong LiuGuoxiong Liu More articles by this author , Dali JiangDali Jiang More articles by this author , Hengtong FanHengtong Fan More articles by this author , Zejun RenZejun Ren More articles by this author , Bing YangBing Yang More articles by this author , Liyue MuLiyue Mu More articles by this author , Dalin HeDalin He More articles by this author , and Lin YangLin Yang More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003219.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Compared with other commercially used lasers, the coagulation layer of the novel 450 nm laser is thinner, and the thickness of the coagulation layer is the key factor affecting the wound healing. In this study, we investigate whether the novel 450 nm 200 W laser system is superior to the classic transurethral resection of the prostate (TURP) for wound healing in beagles. METHODS: Twenty-two 6-8-year-old male beagles were treated with TURP or blue laser vaporization of the prostate (BLVP), and the prostate wound was observed using cystoscopy 3 h, 1, 2, 3, and 5 weeks after the operation (two beagles in each group). Two elderly beagles without the operation were used as the normal controls. After the cystoscopy examination, the prostate was collected and fixed for hematoxylin and eosin (H&E) and immunofluorescence staining, and the dynamic process of wound healing was observed under the microscope. RESULTS: The urethras of the prostates under cystoscopy in the BLVP groups were healed three weeks after surgery, while in the TURP group, they were healed five weeks after surgery. The H&E staining confirmed that the coagulation necrosis layer in the TURP group was thicker than that in the BLVP group, and it took more time to remove the coagulation necrosis after surgery. The change in the macrophage polarity in the BLVP group was also earlier than that in the TURP group. CONCLUSIONS: The new 450 nm 200 W laser was superior to TURP for wound healing. The thinner coagulation layer of the 450-nm laser was the primary reason for this process. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e72 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Xiaofeng Xu More articles by this author Guoxiong Liu More articles by this author Dali Jiang More articles by this author Hengtong Fan More articles by this author Zejun Ren More articles by this author Bing Yang More articles by this author Liyue Mu More articles by this author Dalin He More articles by this author Lin Yang More articles by this author Expand All Advertisement PDF downloadLoading ...