PD01-10 SMALL FIBER POLYNEUROPATHY: A NEXUS LINKING CO-OCCURRING PAIN SYNDROMES IN WOMEN WITH INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME?

Abstract

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Interstitial Cystitis (PD01)1 Sep 2021PD01-10 SMALL FIBER POLYNEUROPATHY: A NEXUS LINKING CO-OCCURRING PAIN SYNDROMES IN WOMEN WITH INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME? Raymond Xu, Tyler Overholt, Catherine A. Matthews, Robert Evans, Gopal Badlani, Christine Ahn, Trang Simon, and Stephen J. Walker Raymond XuRaymond Xu More articles by this author , Tyler OverholtTyler Overholt More articles by this author , Catherine A. MatthewsCatherine A. Matthews More articles by this author , Robert EvansRobert Evans More articles by this author , Gopal BadlaniGopal Badlani More articles by this author , Christine AhnChristine Ahn More articles by this author , Trang SimonTrang Simon More articles by this author , and Stephen J. WalkerStephen J. Walker More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001965.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) often have one or more co-occurring chronic pain syndromes (e.g., chronic pelvic pain (CPP), fibromyalgia (FM), and/or vulvodynia (VD)). The objective of this study was to explore the role of small fiber polyneuropathy (SFPN) as a potential nexus between IC/BPS and chronic pain syndromes. METHODS: Fifty-one women with IC/BPS undergoing therapeutic hydrodistention (HOD) provided a skin biopsy from the distal calf. Processed biopsy tissue was stained with protein gene product (PGP) 9.5, a marker for intraepidermal nerve fibers (IENF), and SFPN (+/-) status was determined by comparing linear IENF density (fibers/mm2; Figure 1) with normative reference values. Co-occurring chronic pain syndrome status (e.g., CPP, FM, and VD) was determined from patient report. RESULTS: Approximately one quarter (13/51; 25.49%) of the women in this cohort were SFPN+. Average age (years) of SFPN+ patients was 40.92 versus 48.73 for patients without SFPN (SFPN-). Among SFPN+ patients, co-occurring widespread pain syndromes were 76.92% (10/13), 46.15% (6/13), and 38.46% (5/13) for chronic pelvic pain (CPP), fibromyalgia (FM), and vulvodynia (VD), respectively. Among the SFPN- patient group, 42.10% (16/38), 36.84% (14/38), and 15.79% (6/38) reported CPP, FM, VD, respectively (Table 1). CONCLUSIONS: Contrary to normative reference range values that show IENF density decreases with age, the SFPN+ patients were, on average, almost 8 years younger than their SFPN- counterparts. SFPN+ women with IC/BPS reported a higher prevalence of chronic pelvic pain, fibromyalgia, and vulvodynia. There was high concordance between SFPN and co-occurrence of CPP (∼77%), suggesting a possible etiological role of SFPN in this generalized pain descriptor. Further studies to determine the mechanisms by which SFPN may contribute to chronic pain syndromes in women with IC/BPS are warranted. Source of Funding: 1R01DK124599-01 (Walker, PI) © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e34-e35 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Raymond Xu More articles by this author Tyler Overholt More articles by this author Catherine A. Matthews More articles by this author Robert Evans More articles by this author Gopal Badlani More articles by this author Christine Ahn More articles by this author Trang Simon More articles by this author Stephen J. Walker More articles by this author Expand All Advertisement Loading ...