Abstract
ABSTRACT Introduction Radiofrequency ablation (RFA) and stereotactic radiation are treatment possibilities for unresectable colorectal liver metastases. In this analysis the efficacy of RFA and robotic radiosurgery (RRS) was compared in a total of 60 patients. Methods The authors prospectively followed 30 patients with colorectal liver metastases not qualifying for surgery who were treated in curative intent with RRS. To compare efficacy of both treatment modalities, patients treated with RFA during the same period of time were matched according to number and size of the treated lesions. Local tumor control, local disease-free survival (local DFS), and disease-free survival (DFS) were analyzed to evaluate the efficacy. Treatment related side effects were recorded for comparison. Results The median maximum diameter of the matched lesions was 33 mm (7-53 mm). Baseline characteristics did not differ significantly. Local control rate showed a significant difference and favored RRS (76.6% vs. 40.0%; p = 0.008). This related to a significantly longer local DFS of patients treated with RRS compared to RFA (34.4 months vs 7.1 months for RFA; p Conclusion Single session robotic radiosurgery (RRS) is a safe and effective method to treat colorectal liver metastases. In this analysis, local tumor control achieved by RRS was superior to RFA treatment.
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