Abstract
It is well known that the activity of a supported catalyst is deeply dependent on the physicochemical properties of the support material that include fabric, size, shape, steric structure, and dispersion of the supported metal. We have developed a chemoselective hydrogenation method using a heterogeneous zero-valent palladium catalyst supported on spherical carbon (Pd/SC) with a large average diameter (0.36 mm). Pd/SC was found to be an efficient catalyst for the hydrogenation of alkyne, alkene, azido, nitro, and aliphatic O-tert-butyldimethylsilyl (TBS) functionalities without the hydrogenolysis of benzyl ester and ether, nitrile, aromatic ketone, aromatic O-TBS, and N-carbobenzyloxy (N-Cbz) functionalities. The present method is promising as a general, practical, and chemoselective hydrogenation process.
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