Abstract
The first enantioselective Pd-catalyzed cyclization of 1,6-enynes containing silyloxy-substituted olefins is demonstrated using two chiral Pd complexes. Catalyst A required higher catalyst loading and longer reaction times compared to catalyst B. Catalyst B was highly active and selective for a wider scope of substrates, including O-silyl ketene aminals and indoles. Good to excellent yields and enantioselectivities were seen for both catalysts. The reaction’s synthetic utility was shown by the synthesis of the sesquiterpene (-)-laurebiphenyl.
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