生物标志物在阻断PD-1/PD-L1通路治疗肿瘤中的预测性作用

Abstract

Identifying biomarkers predicting clinical response to treatment of PD-1/PD-L1 pathway blockade can guide patient selection and therapeutic individualization. Some researches have shown that patients with cancer will acquire better clinical effects by blocking PD-1/PD-L1 pathway whose characteristics include higher pretreatment expression of PD-L1 by tumor cells or tumor infiltrating immune cells, the massive infiltration of intratumoral CD8+ T cells, the high mutation frequency of tumor cell gene. These biomarkers are expected to become indicators which can select patients. Key words: Neoplasms; Therapy; Biological markers; PD-1/PD-L1 pathway