PD-1 is a marker of activation on tumor infiltrating NK cells in head and neck cancer

Fernando Concha-Benavente,Robert L Ferris,Raghvendra M Srivastava,Benjamin Kansy

doi:10.1186/2051-1426-3-s2-p398

Abstract

Meeting abstracts Co-inhibitory immune checkpoint receptors have become important targets for cancer immunotherapy. Programmed death 1 (PD-1) has been well-characterized on T cells in many cancer types, including head and neck cancer (HNC), for its ability to mediate activation and eventually T

Highlights

Co-inhibitory immune checkpoint receptors have become important targets for cancer immunotherapy
Programmed death 1 (PD-1) is a marker of activation on tumor infiltrating NK cells in head and neck cancer
It is necessary to investigate how cetuximab modulates activation of immune effector cell infiltrates in the tumor microenvironment in order to improve or extend its therapeutic efficacy

Summary

Introduction

Co-inhibitory immune checkpoint receptors have become important targets for cancer immunotherapy. PD-1 is a marker of activation on tumor infiltrating NK cells in head and neck cancer Fernando Concha-Benavente1*, Raghvendra M Srivastava2, Benjamin Kansy3, Robert L Ferris2 From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA.

Results

Conclusion