Abstract
Objective: PD-1 is an immunoinhibitory receptor which plays vital role in pathogenesis of hepatitis B virus (HBV) infection. The aim of this study was to understand the relationship between PD-1.1 polymorphism in HBV infection and liver disease progression. Subject and method: 154 chronic hepatitis B virus (CHB), 127 liver cirrhosis (LC), 186 hepatocellular carcinoma (HCC) and 160 healthy controls. The PD-1.1 polymorphism was genotyped by directed Sanger sequencing. Result: The PD-1.1 TT genotype was found to be a risk factor for LC predisposition of CHB patients. Conclusion: The PD-1.1 polymorphisms are related to the progession of HBV-related liver disease, especially as a prognostic factor for cirrhosis liver in patients with chronic hepatitis B.
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