PCR53 Efficacy of Dupilumab in Patients with Uncontrolled, Moderate-to-Severe Asthma and with High Sleep Disturbance: A Post Hoc Analysis from Liberty Asthma Quest

Abstract

Patients with asthma often experience sleep disturbances, which can be associated with poor asthma control. This post hoc analysis used a composite criteria based on validated patient-reported outcomes to identify patients with HSD. Efficacy of dupilumab vs placebo in improving sleep quality and other clinical/patient-reported outcomes in patients with uncontrolled, moderate-to-severe asthma with elevated type 2 biomarkers, 5-item asthma control questionnaire (ACQ-5) scores ≥2.5, and high sleep disturbance (HSD), at baseline of phase 3 QUEST (NCT02414854) is reported.