Abstract
To perform a systematic review and meta-analysis of all randomized controlled trials comparing efficacy of Intermittent versus continuous chemotherapy (CT) for first-line treatment of unresectable Metastatic Colorectal Cancer (CCRm). Several databases were searched, including MEDLINE, EMBASE, LILACS, and CENTRAL. The primary endpoint was overall survival (OS). The data extracted from the studies were combined by using Hazard Ratio (HR) with their corresponding 95% confidence intervals (CI95%). Overall, 733 references were identified and screened. The final analysis included 4 trials comprising 1,827 patients analyzed. There was no statistically significant difference between the groups (Intermittent vs continuous chemotherapy) on the analysis of overall survival (fixed effect: HR=1.03, CI95%=0.92 to 1.16; p=0.56). No heterogeneity was detected on this analysis (Chi2 = 2.88, df = 3 (P=0.41); I2 = 0%). Overall survival was similar between groups. The intermittent chemotherapy regimen provides better quality of life that the scheme is continued and probably cost saving.
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