PCN111 Incidence and Long-Term Survival of Cervical Cancer Patients in the United States, an Analysis of SEER Database

Abstract

Cervical cancer in the United States has decreased substantially since the implementation of widespread screening and prevention measures. This study examined the patterns in incidence and survival rates for cervical cancer in recent years. Using Surveillance, Epidemiology, and End Results (SEER) population-based data, we identified patients with cervical carcinoma (ICD-03: C53.x) diagnosis between January 01, 2005, and December 31, 2017. We calculated annual, age-adjusted incidence rates of cervical carcinoma per 100,000 individuals by age, race/ethnicity, stage at diagnosis, and histologic type. Kaplan Meier method was used to obtain five-year cancer-specific survival rates. According to SEER, there were 41,378 cervical carcinoma patients between 2005-17. About 81.4% of cervical cancer cases were aged below 65 years. The incidence rates were substantially higher among blacks (8.1; standard error [SE]=0.1) and Hispanics (9.2; SE=0.1) as compared to whites (7.2; SE=0.0). Compared to other stages and histologic types, higher incidence rates were observed for localized stage (3.4; SE=0.0) and squamous cell carcinoma (5.0; SE=0.0). The overall 5-year cancer-specific survival rate was (71.7%; SE=0.3), while it was highest for adenocarcinoma (77.2%; SE=0.5) histology type. Incidence rates and survival rates declined from 7.6 (SE=0.1) in 2005 to 7.0 (SE=0.1) in 2012 and 72.2% (SE=0.8) in 2005 to 70.6% (SE=0.9) in 2012, respectively. However, there was a gradual increase in the incidence rates from 2.8 (SE=0.1) to 13.5 (SE=0.1) amongst women below 50 years. Even though the overall incidence rate is on the decline, there was a noticeable increase in incidence amongst patients under 50 years. A significant decrease in the 5-year survival rate was also observed. These patterns warrant concerted efforts to increase the early prevention and screening of cervical cancer.