Abstract
PCH'ing Together an Understanding of Crossover Control
Highlights
It should be no surprise that most eukaryotes possess a sophisticated mechanism to control meiotic recombination
It has been shown that when the number of doublestrand breaks (DSBs) is reduced, crossovers tend to be maintained at the expense of non-crossovers [7,8]
It has been proposed that the obligate crossover, crossover interference, and crossover homeostasis are all manifestations of a single or closely related set of molecular processes, but this hypothesis remains to be rigorously tested [7,9,10]
Summary
It should be no surprise that most eukaryotes possess a sophisticated mechanism to control meiotic recombination. Most of the proteins that have been shown to influence crossover control in budding yeast appear to function downstream of the crossover/noncrossover decision. One such class of proteins, commonly referred to as ZMMs (Zip1/2/3/4, Msh4/5, Mer3), is required for the repair of DSBs into crossovers that exhibit interference [2].
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