Abstract
ABSTRACTBackground:The association of prostate cancer antigen 3 (PCA3) polymorphism (SNP, rs544190G>A) with metastatic prostate cancer in European descent has been reported. Our aim of the current study was to re-validate the effect of PCA3 polymorphism on prostate cancer risk in an Eastern Chinese population and then estimate possible genetic discrepancies among population.Materials and Methods:Taqman assay was employed to determine genotype of SNP rs544190 in 1015 ethnic Han Chinese patients with prostate cancer and 1032 cancer-free controls. Simultaneously, odds ratios (OR) and 95% confidence intervals (95%CI) for risk relationship were calculated by logistic regression models.Results:The statistically significant relationship between PCA3 rs544190G>A and higher prostate cancer risk was not found. Stratification analysis revealed that there was no remarkable association of rs544190 variant AG/AA genotype with prostate cancer risk in every subgroup, except for patients with Gleason score ≤7(3+4).Conclusion:Although the results demonstrated that SNP rs544190 was not involved in prostate cancer risk in Eastern Chinese descent, unlike in European population, these might have clinical implications on prostate cancer heterogeneity around the World. To validate these findings, well-designed studies with different ethnic populations are warranted.
Highlights
In the Western male population, prostate cancer is the most commonly diagnosed carcinoma and the second leading cause of cancer-related deaths [1]
Single nucleotide polymorphisms (SNPs) have been studied and used to track cancer-causing genes [7], and the analysis of single nucleotide polymorphisms (SNPs) may assist in the development of new mechanism and agents for treating cancer
1032 cancer-free controls of ethnic Han Chinese in Eastern China were recruited from the Taizhou Longitudinal (TZL) study with the selection criteria containing no individual history of cancer [19]
Summary
In the Western male population, prostate cancer is the most commonly diagnosed carcinoma and the second leading cause of cancer-related deaths [1]. Prostate cancer is not easier to occur in individuals of Asian ancestry than in their white and African counterparts, and Asian descent who live in diverse environment around the World still have low risk of developing prostate cancer [4,5,6] Based on these evidences, some genetic factors represented individual characteristics may contribute to the diverse mechanism for prostate carcinogenesis among ethnic populations. Conclusion: the results demonstrated that SNP rs544190 was not involved in prostate cancer risk in Eastern Chinese descent, unlike in European population, these might have clinical implications on prostate cancer heterogeneity around the World. To validate these findings, well-designed studies with different ethnic populations are warranted
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