Abstract
Suboccipital nerve stimulation activates the dorsal rostral pons and anterior cingulate cortex [1, 2], centers that are implicated in mediating endogenous pain modulation (EPM) [3, 4]. Indeed, direct current stimulation (DCS)-mediated pain modulation following suboccipital nerve stimulation in people with chronic pain [5, 6] suggests that the effect of noninvasive DCS applied at the suboccipital (SO) level may indirectly influence EPM. The aim of this study was to evaluate whether a single-session of anodal SO-DCS could potentiate EPM measured as conditioned pain modulation of tonic heat pain intensity in healthy participants, and to compare this effect with observations induced with M1 cortical direct current stimulation [7].
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