Abstract

Focal brain damage associated to stroke is the cause of large-scale network dysfunctions resulting in enduring motor sequels1. Transcranial direct current stimulation (tDCS) studies have shown promise in restoring local activity and network balance. Yet, clinical outcomes on complex functions such as gait remain inconsistent, highlighting the need to design and test innovative tDCS interventions2. To this regard, we here considered and assayed for the first time a dual-site multi-domain intervention approach based on the simultaneous modulation of two different set of systems (pre-frontal and cerebellar) both synergistically contributing to the recovery of gait after stroke3.

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