Abstract
18-Fluorine fluorodeoxyglucose (FDG) PET-CT is a sensitive technique and hypermetabolic foci unrelated to the primary malignancy are not infrequently encountered. The aim of this study was to evaluate the clinical significance of unexpected focal FDG uptake within the breast in patients undergoing PET-CT for assessment of other malignancies.
Highlights
Previous research in this centre enabled the introduction of a local protocol of nonbiopsy and discharge of women
Mammography-detected cancers were luminal in 77% (P = 0.03), node negative in 77% (P = 0.005), with ductal carcinoma in situ (DCIS) in 81% (P = 0.007)
We applied our approach to 13 experienced readers assessing 13,694 screening mammograms from a large clinical study where women are categorised as high risk if they have a 5 to 8% 10-year risk computed by a validated risk model and their breast density is in the top decile of the study population
Summary
Previous research in this centre enabled the introduction of a local protocol of nonbiopsy and discharge of women
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