PB2373 LIVER DISEASE DURING AND AFTER AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION IN EGYPT (SINGLE CENTER EXPERIENCE)

Abstract

Please indicate where the abstract has been published before: egyptian socitey of hepatology and gastroenterology journalBackground:Hematopoietic stem cell transplantation has a rapid increase over the last decade. It is an established therapy for many hematological disorders. HSCT had many possible serious complications. One of those complications is hepatic dysfunction.Hepatic complication in autologous HSCT survivors could be early complications include drug toxicity, infections and long‐term liver complications from chronic viral hepatitis, iron overload or original disease relapse.Aims:is to determine the prevalence, etiology of liver disease in Egyptian population who had HSCTMethods:this study is cross‐sectional study in December 2016 including 88 patients who had autologus transplantation in Ain Shams University HospitalsResults:In autologus patients the first cause of hepatotoxicity is conditioning regimen involving 27% of the patients. Second cause is flare of viral hepatitis affecting 8% of the patients. In third place is sepsis that leads to elevated liver function which occurred in 6% of our patients, these figures were also dramatically changed after D + 100 and lower hepatotoxicity percentage occurs as 11% of the patients had liver injury caused by drugs and only 1% patients had viral hepatitis reactivation.imageSummary/Conclusion:Drug hepatotoxicity is main cause of liver injury in BMT unit in Ain Shams University in Egyptian population.