PB2289 HEALTH‐RELATED QUALITY OF LIFE AND OXYGEN TRANSPORT IN PATIENTS WITH NEPHROGENIC ANEMIA

Abstract

Background:End‐stage renal disease (EsRD) is often associated with an anemia. Most patients retrieve erythropoiesis stimulating agents, and so they presents with mild anemia. The tolerance of anemia of each patient is individual. Determination of venous blood gas (VBG) in conjunction with study of health‐related quality of life (HRQoL) can help in the individualization of treatment.Aims:To investigate the relationship between health‐related quality of life and venous blood gas in patients with nephrogenic anemia.Methods:30 patients with EsRD undergoing hemodialysis and receiving erythropoes stimulating therapy were involved in the study. 20 men, median age 52 years. Polycystic kidney disease was caused by the development of EsRD in 7 (23%) patients, diabetic nephropathy in 6 (20%) patients, glomerulonephritis also in 6 (20%) patients, nephrosclerosis in 5 (17%), and other causes in the remaining 6 patients (20%). HRQoL was studied using the FACT (Functional Assessment of Cancer Therapy Scale) questionnaire. Indicators of complete blood count, VBG were evaluated.Results:The hemoglobin median in the studied patients showed 105 g/l (81‐112 g/l), 26 patients experienced mild anemia (87%), 3 patients (10%) ‐ moderate anemia. in 1 patient there was no anemic syndrome. SvO2 median is 62.3%, while in only 18 (60%) patients the level of SvO2 is ≥60%. In general, the results of HRQoL analysis showed its deterioration in patients on all scales of the FACT questionnaire; the highest score was obtained in the scales “Physical well‐being” (Me 11 points) and “Anemia” (Me 30 points). When conducting a correlation analysis of hemoglobin and HRQoL, a statistically significant relationship was found on the scales “Physical well‐being” (r = ‐0.45; p < 0.05), “Emotional well‐being” (r = ‐0.39 p < 0, 05) and Anemia (r = ‐0.51; p < 0.05). A statistically significant correlation was obtained between the level of hemoglobin and the level of oxygen in venous blood. At the same time, no significant correlation was established between HRQoL and the saturation of venous blood (p > 0.2).Summary/Conclusion:According to the results of the HRQoL analysis, it was established that in patients with nephrogenic anemia, HRQoL decreases depending on the concentration of hemoglobin. The generally accepted target level of hemoglobin (100‐110 g/l) allows to avoid severe complications, but not in all cases it can adequately meet the need for O2 in patients. According to the data obtained, only 60% of patients achieved SvO2 ≥ 60%, which indicates the presence of tissue hypoxia.