PB2079: INTERIM REPORT OF BENDAMUSTINE PLUS RITUXIMAB AS FIRST-LINE INDUCTION THERAPY WITH OR WITHOUT LENALIDOMIDE MAINTENANCE THERAPY IN CHINESE PATIENTS WITH INHL OR EMCL: A MULTI-CENTER PROSPECTIVE TRIAL

Abstract

Background: Bendamustine plus rituximab (BR) was established as a preferred first line therapy for patients with previously untreated indolent non-Hodgkin’s lymphoma (iNHL) and elderly MCL (eMCL) based on the BRIGHT and STiL trials. But the data is rare from Chinese patients because the unavailability of bendamustine. Furthermore, the safety and efficacy of maintenance therapy with rituximab remained contradictory after BR induction therapy, due partly to the durable immuno-supression of bendumustine. On the other hand, lenalidomide, as a proven effective agent for iNHL and MCL, have immune modulatory function. So, as maintenance therapy after BR induction, lenalidomide may increase response rate and prolong progression free survival (PFS) for iNHL and eMCL. Aims: To assess the efficacy and safety of BR regimen for Chinese patients with iNHL and eMCL. And more importantly, to assess the efficacy and tolerability of lenalidomide as maintenance therapy after BR. Methods: We conducted a multi-institutional, prospective, non-randomized clinical trial for patients with iNHL and eMCL. The patients received standard six cycles of BR regimen as induction therapy, and then received lenalidomide (10mg, qd) maintenance vs. no maintenance, from December 2020 to February 2022. Patients with iNHL and elderly MCL who received at least two cycles of BR were evaluated. The primary endpoint of the study was progression-free survival (PFS). Results: Overall, 61 patients enrolled in the study, baseline characteristics of cohort were shown in Table 1. Median age at BR initiation was 55 years (range 24-74), 73.8% had ECOG 0-1, and 26.2% ECOG 2. Follicular lymphoma (FL) (62.3%) and marginalzone lymphoma (MZL) (24.6%) were the main subtypes of iNHL. The proportion of elderly MCL was 9.8%. Most patients were in stage 3 (9.8%) and stage 4 (72.1%). All patients have indication for systemic therapy. Till the date of February 10, 2022, a total of 85.2% completed 4 cycles induction therapy. Overall response was 94.2%, with 82.7% complete response (CR) and 11.5% partial remission (PR), (Figure 1). Progression during induction occurred only in one MCL patients. And another two patients with FL was suspected progressive disease during observation (no lenalidomide maintenance). After 4 cycles induction therapy, PET/CT detected in 40 patients (76.9%), while CT or MRI detected in 12 patients (19.7%). Among the 39 patients with complete remission assessed by PET-CT, 8 patients (20.5%) of them had residual lymph nodes with diameter > 1cm. So the CRR by CT is 67.3%, which is much higher than that reported in STiL study and BRIGHT study. The safety profile of BR regimen was shown in Table 2. Hematological toxicities was the main adverse events, with grade 3-4 neutropenia was recorded in 21.3%, febrile neutropenia in 8.2%, grade 3-4 anemia in 3.3%, and grade 3-4 thrombocytopenia in 1.6% of patients. The rate of fatigue, nausea/vomiting, skin rash and infections were less than 15%. A total of 40.0% patients proceeded to lenalidomide maintenance. However, 10% patients discontinued because of rash or other adverse reaction to lenalidomide. Image:Summary/Conclusion: BR regimen was feasible, safety and got high CRR for Chines iNHL and eMCL patients by our clinical trial. The efficacy and safety of maintenance lenalidomide after BR induction are still under follow-up. This trial was registered at http://www.chictr.org.cn. Clinical trial information: ChiCTR2200056288.