PB2036 EFFECTS OF DIFFERENT IRON FORMULATION SUPPORT ON SELECTION OF SOME PATHOGENS IN HUMAN GUT FLORA: MONOCENTRIC STUDY

Abstract

Background:Food and micronutrients support modify the composition of our intestinal flora.Aims:Aim of this study is to see how different iron formulations used in human iron support are able to expand gut pathogen flora.Methods:36 female patients (6 per group) with sideropenic anemia due to hypermenorrhea received 60 mg/day of different iron formulations: sulphate, Sucrosomial®, heminic bisglycinated, bisglycinated chelated, micronized encapsulated.Median age of patients was 30y (R20‐38). A stool culture test was performed in each patient at start of treatment and one month after. If at time 0 a culture was positive for a pathogen, patient was excluded from the study.Cultural stool test were performed for E. coli enteropathogen, enterohemorragic, salmonella, shigella, clostridium, yersinia entherocolica.Results:Before treatment: 1 patient receiving iron sulphate had a yersinia positivity and 1 receiving heminic bisglycinated iron showed an E. coli.After treatment: 2 patients receiving heminic bisglycynated iron showed positivity for E. coli enteropathogenic, 1 for shigella; 4 patients receiving iron sulphate showed positivity for E. coli enteropathogenic; 2 patients receiving micronized encapsulated iron and 2 with bisglycinated chelated iron showed positivity for E. coli enteropathogenic, 1 with Sucrosomial® iron showed positivity for yersinia enterocolica.Summary/Conclusion:Different type of iron supplements differently affect pathogen gut flora selection. Molecular complexes iron carriers probably influence differently pathogen selection. The most represented selected pathogen flora is E. coli entheropathogenic.