PB1735 POSTDIAGNOSIS SMOKING WITH RISK OF ALL‐CAUSE AND CANCER MORTALITY AMONG LEUKEMIA SURVIVORS: A PROSPECTIVE COHORT STUDY

Abstract

Background:Smoking is associated with higher leukemia risk, but smoking and risk of all‐cause and cancer mortality among leukemia survivors is unclear.Aims:To evaluate more thoroughly the risk of all‐cause and cancer mortality between cigarette smoking and leukemiaMethods:We identified 316 subjects who were diagnosed with leukemia from National Health Interview Survey participants≥18 years of age from 13 cross‐sectional waves conducted during 1997 to 2009 (linked to mortality data in 2015) at baseline. Cox proportional hazards regression models were used to calculate adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for the risk of all‐cause and cancer mortality caused by smoking exposure.Results:After a median follow‐up of 13 years, 141 (50%) were alive and 141 (50%) died due to all‐cause mortality during the follow‐up. Of all the patients who died, 70 (50%) died due to cancer and 20 (14%) died due to cardiovascular disease (CVD). Compared to never smokers, former smoking could increase the risk of cancer mortality (HR, 1.95; 95%CI, 1.04‐3.68), especially for those who quit smoking recently (HR, 2.59; 95%CI, 1.17‐5.74). For cancer mortality, dose relationship was obvious among former smokers who had quit more recently than for those who had quit earlier with a “U” shaped curve (Ptrend < 0.05). Current smokers who smoke less than 10 cigarettes per day had higher risk of cancer mortality (HR, 3.72; 95%CI, 1.01‐13.73) than never smoking when patients with a history of CVD were excluded.Summary/Conclusion:This study adds to the existing evidence that cigarette smoking is associated with higher cancer mortality among leukemia patients, especially for former smokers.image