Abstract
There are few data regarding the effect of neoadjuvant chemotherapy (NACT) and trastuzumab on any ductal carcinoma in situ (DCIS) associated with the HER2-positive invasive carcinoma. HER2-positive breast cancers are more likely to achieve a pathological complete response (defined as absence of invasive tumour in the final excision specimen allowing for the presence of DCIS). We review our data to see what happens to HER2-positive DCIS associated with HER2-positive invasive cancer treated with NACT.
Highlights
Breast Cancer Research 2014, 16(Suppl 1):O1. This multicentre randomised controlled trial investigated whether a computed tomography (CT) scan of the axilla could more accurately assess whether the axillary lymph nodes were involved with malignancy in patients with newly diagnosed breast cancer and influence surgical decision-making with regard to axillary surgery
This study evaluated breast volume measurements calculated by Volpara® breast density software, by comparing them with actual mastectomy volumes
The excellent correlation between Volpara® and sparing mastectomy (SSM) volumes suggests that this readily available and convenient preoperative measure of breast volume could be used as a tool to aid surgical planning in women with breast cancer, which might be useful in those women not scheduled for preoperative Magnetic resonance imaging (MRI)
Summary
Completeness of excision is the most important factor influencing local recurrence for invasive breast cancer. The aim of this study was to determine whether or not radiological underestimation of tumour size increased the risk of incomplete excision in patients undergoing breast-conserving surgery (BCS). T stage, maximum tumour diameter, multifocal disease, an in situ component and mammographical underestimation all significantly increased the risk of incomplete excision when applied to a best-fit model. The larger the size of the in situ component, the greater the risk of both radiological underestimation and incomplete excision. Conclusion: Underestimation of tumour size by current radiological techniques increases the risk of incomplete excision in women undergoing BCS. Extent of agreement between radiological and pathological size and factors affecting completeness of excision in breast-conserving surgery for invasive breast cancer.
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