Abstract
ObjectiveTo determine the efficacy of pazopanib eye drops in the streptozotocin induced diabetic retinopathy rat model. MethodsA 0.5% w/v pazopanib suspension was prepared in phosphate buffered saline (PBS, pH 7.4) in the presence of 0.5% w/v sodium carboxymethyl cellulose. Brown Norway rats were divided into three groups (n=4) — (1) healthy, (2) diabetic, and (3) diabetic with treatment. The drug suspension was administered twice daily as eye drops to group 3 for 30days. Efficacy parameters including the number of adherent leukocytes in the retinal vasculature (leukostasis), blood–retinal FITC-dextran leakage, and vitreous-to-plasma protein ratio were measured. ResultsPazopanib suspension in the form of eye drops significantly reduced leukostasis (32%), FITC-dextran leakage (39%), and the vitreous-to-plasma protein ratio (64%) in diabetic animals compared to untreated diabetic group. ConclusionPazopanib eye drops can alleviate retinal complications of diabetic retinopathy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
