Abstract
Differentiation of somites leads to the development of dermomyotome and sclerotome with the latter forming after an epithelial-mesenchymal transition of the ventral part of the somite. Inductive effects of the notochord are required for differentiation of the sclerotome and for proper formation of the axial skeleton, the inductive effect of the notochord being mediated bysonic hedgehog(SHH), the mammalian homologue of theDrosophilasegment polarity genehedgehog. Shh acts by antagonizing the activity of the cAMP dependent protein kinase A (Pka).Pax1andPax9are paired box containing genes expressed in the developing sclerotome that may be involved in mediating the inductive effects of the notochord. Loss ofPax1function in mice leads to severe abnormalities in sclerotome differentiation and vertebral column formation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
