Abstract
Patulin is a toxic metabolite of several species of the genera Aspergillus and Penicillium. When administered to 10–15-g Swiss ICR mice by the oral, sc and ip routes, the 72-hr LD 50 values were: oral 48·0, sc 10·0 and ip 7·5 mg/kg body weight. Gross lesions consisted of gastric and duodenal hyperaemia and intestinal distention. Histopathological lesions included ulceration and inflammation of the stomach and intestines. Mortality was greatest 0–24 hr post-administration when patulin was administered by oral and sc routes, but most deaths occurred after 49–72 hr in the ip-dosed group. When patulin was administered orally to mice daily or on alternate days for 2 wk at doses of 50 or 75% of the oral LD 50 mortality was dose-dependent and no cumulative toxicity was indicated. The cause of death and the lesions were attributed to enterotoxaemia from alteration of the gastro-intestinal flora by patulin's antibiotic activity.
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