Abstract
Purpose:To describe the demographic and clinical patterns of patients with uveitis referred to a tertiary center in northeastern Iran.Methods:This cross-sectional retrospective study included 235 patients with uveitis who had been referred to the uveitis clinic of Khatam-Al-Anbia eye hospital, affiliated to Mashhad University of Medical Sciences, from February 2013 to March 2014. Data regarding patient age, sex, anatomical location of the disease, and etiologic and clinical features were analyzed.Results:Mean patient age at the onset of uveitis was 35.75 ± 16.3 (range: 3–82) years. The ratio of females to males was 1.5 to 1. Sixty-four percent had bilateral involvement. The predominant type of inflammation was non-granulomatous (76%). Panuveitis (46.8%, 110 cases) was the most common form of uveitis followed by anterior (37%, 87 cases), intermediate (11.9%, 28 cases), and posterior uveitis (4.25%, 10 cases). The most common diagnoses were “idiopathic” in anterior and intermediate uveitis cases, toxoplasmosis in posterior uveitis group, and Behçet and Vogt-Koyanagi-Harada diseases in panuveitis cases. Overall, noninfectious causes (80.42%) of uveitis were more frequent than infectious causes (19.57%). The proportion of noninfectious uveitis was 82.75% in anterior uveitis, 78.18% in panuveitis, 92.85% in intermediate uveitis, and 50% in posterior uveitis. The most common associated systemic disease was Behçet disease.Conclusion:In contrast to most epidemiologic studies of uveitis, the clinical and etiologic patterns of uveitis were different in a tertiary referral center in northeastern Iran. Panuveitis was the most common clinical pattern in this study, and the most common associated systemic disease was Behçet disease.
Highlights
IntroductionUveitis is a vision threatening intraocular inflammatory disease of uveal tissues with or without involvement
The following laboratory tests tailored to eye examination, systemic symptom associations and most probable differentials were conducted: complete blood count, erythrocyte sedimentation rate, C‐reactive protein level, urinalysis, venereal disease research laboratory test or fluorescent treponemal antibody‐absorption for syphilis, polymerase chain reaction (PCR) of aqueous or vitreous humor for herpetic and cytomegalovirus uveitis, chest X‐ray (CXR) or high‐resolution computed tomography (CT) of the chest for sarcoidosis and tuberculosis (TB), sputum smear and culture and purified protein derivative (PPD) skin test for TB, antinuclear antibody testing, antineutrophil cytoplasmic antibody testing, angiotensin‐converting enzyme level, human leukocyte antigen (HLA) typing, sinus, sacroiliac and brain imaging, and skin and mucus membrane biopsy
The diagnosis of infectious uveitis was based on typical clinical findings, serology confirmation, eyelid skin biopsy, PCR result (CMV, HSV, and TB), CXR or chest CT, and PPD skin test (TB)
Summary
Uveitis is a vision threatening intraocular inflammatory disease of uveal tissues with or without involvement. It can be induced by infectious or non‐infectious etiologies, as well as by a variety of systemic diseases. If not managed in a timely manner, uveitis leads to severe vision loss. Uveitis is estimated to be the cause of 5–10% of blindness or visual impairment worldwide.[1] Up to 20% of legal blindness in developed countries can be attributed to complications of uveitis.[2,3,4,5,6,7] Uveitis most often affects patients of working age (20–50 years);[5,6]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
