Abstract
Abstract The concentration of alkaline phosphatasc in normal urines has been reported as being very low. The present work has confirmed this finding and established a normal range of 0.1–1.0 K.A./100 ml and 1–11 K.A. per 24 h. The presence of an inhibitor which masks some of the enzyme activity but which can be removed by dialysis was confirmed. In serial studies of patients with acute renal failure the normal values were found often to be exceeded. Particularly striking was the great increase in concentration and daily output of the enzyme that occurred with, or just after, the onset of diuresis. Elevations of enzyme activity characteristically took the form of peaks of short duration separated by troughs of lower levels. The origin of the peaks of high phosphatase excretion and their clinical significance are discussed.
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