Abstract
The immunological profiles of human specific IgE (sIgE) and specific IgG4 (sIgG4) vary by genetic predisposition, living conditions in different geographical locations and patient’s age. The aim of our study was to analyze sIgE and sIgG4 patterns and their age-dependent changes in patients from the Moscow region. For identifying sIgE and sIgG4 profiles the blood samples from 513 patients aged 6 months to 17 years who were showing symptoms of allergic diseases were analyzed using microarrays containing 31 allergens. The highest sIgE prevalence was observed for birch pollen (32%) among pollen allergens, cat dander (24%) among indoor allergens, and egg whites (21%) among food allergens. The most common sIgG4 response was developed toward egg whites (80% of patients). Age-related elevation was identified for patients with increased sIgE to pollen allergens and indoor allergens (cat or dog dander and house dust mites). For each allergen, the proportion of cases with significant levels of sIgG4 appeared to increase with patients’ age. The data on allergen-specific sIgE and sIgG4 prevalence show both general trends and some local special aspects that are indicative for the Moscow region. This information should be useful in terms of epidemiology of allergic diseases.
Highlights
Up to 20% of the adult population of developed countries and up to 40–50% of school children are affected by different allergic diseases [1]
Allergen-specific immunoglobulin E is the main marker of type I hypersensitivity reaction to a certain agent. sIgE bound to an allergen is involved in the process of cross-linking
Significant male/female differences (p
Summary
Up to 20% of the adult population of developed countries and up to 40–50% of school children are affected by different allergic diseases [1]. It is well known that the formation of allergic diseases is associated with the increase in skin and mucus barrier permeability and based on genetic predisposition and adverse environmental conditions [2]. The recognition of allergens leading to certain adverse symptoms in different geographical regions is becoming more important for general allergology and for the development of efficient methods of allergy diagnostics. Allergen-specific immunoglobulin E (sIgE) is the main marker of type I hypersensitivity reaction to a certain agent. SIgE bound to an allergen is involved in the process of cross-linking.
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