Patterns of oxalate metabolism in recurrent oxalate stone formers

Abstract

Patterns of oxalate metabolism in recurrent oxalate stone formers. The concentration of oxalate in the blood (isotopic procedure), the renal clearance of oxalate, the rate of 14 C-oxalate excretion in the urine and the intestinal absorption of 14 C-oxalate were used as indexes to classify different disturbances of oxalate metabolism in recurrent oxalate stone formers with hyperoxaluria. By comparison with a control group, three major patterns of oxalate metabolism were found. The first group had normal concentrations of blood oxalate, an increased excretion rate of isotopic oxalate and higher oxalate clearance. The second group had higher concentrations of blood oxalate, decreased 14 C-oxalate excretion and normal or decreased oxalate clearance. Finally, in the third group an increased oxalate absorption rate was the main alteration.