Patterns of Mismatch Negativity Deficits in Individuals at Clinical High Risk for Psychosis and Association with Symptoms

Abstract

Auditory processing deficits are core to schizophrenia, reflected in impaired generation of EEG-derived event-related potentials such as the auditory mismatch negativity (MMN), elicited in response to deviant stimuli. Among individuals at clinical high risk (CHR) for psychosis, auditory MMN impairments exist and predict an outcome. We hypothesized that auditory MMN deficits in CHR patients would be associated with symptom severity.