Abstract
Purpose The present study evaluated the expression of alpha 1-adrenoceptor subtypes in human corpus cavernosum. Materials and Methods The mRNA encoding alpha 1a, and alpha 1b and alpha 1d subtypes were assessed by RNA-directed complementary cDNA synthesis followed by Taq DNA amplification. The level of alpha 1 mRNA was calculated in arbitrary optical density units and normalized with respect to the length of the respective cDNA fragments. Results We found that alpha 1a, alpha 1b and alpha 1d adrenoceptor subtypes are expressed in human corpus cavernosum, with a predominant expression of the alpha 1a subtype. Conclusion These results suggest that alpha 1a-adrenoceptor subtype is important and that understanding the biochemical and functional characteristics of this subtype may lead to the development of specific antagonists in the treatment of impotence.
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