Abstract
Summary Basal acid output (BAO), peak acid output (PAO), BAO:PAO ratio, and extent of inhibition of gastric acid secretion by medical vagotomy were determined in a small series of male patients with duodenal ulcer. In general, there was a lack of correlation between these measurements and independently assessed clinical and psychiatric features. A positive correlation between BAO and PAO was observed at all levels of secretion. When only those patients with very low or very high BAO were studied, depression was found to be the predominant characteristic among 8 patients with low BAO and low PAO while anxiety was the outstanding feature present in 8 patients with low BAO and high PAO. Inhibition of stimulated secretion by medical vagotomy was more marked among those patients with high BAO and high PAO. The results confirm the wide variation in gastric secretory patterns previously observed among duodenal ulcer patients.
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