Abstract
Patterns of failure were evaluated for 343 patients with inoperable bronchogenic carcinoma confined to one hemithorax. Patients with both small cell and non-small cell carcinoma were treated with either chest irradiation or chest irradiation plus brain irradiation. The pattern of failure depended upon the histologic type. Patients with small cell carcinoma were most likely to exhibit disseminated disease (53%) prior to recurrence of local disease. Patients with adenocarcinoma and large cell carcinoma also had a similar tendency (40%), as opposed to patients with squamous cell carcinoma (20%). The occurrence of objective tumor regression improved survival but did not appear to alter the pattern of failure. Because of this tendency for local control to delay the overall disease process, therapy for these patients should concentrate on the local disease.
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