Patterns of Deranged Lipid Profiles in Patients of Chronic Hepatitis C

Abstract

Liver plays an important role in lipid metabolism and any acute or chronic malfunction of theliver due to viral hepatitis or liver cirrhosis may induce lipid derangements Objective: To determine thepatterns of deranged lipid profiles in patients of chronic hepatitis C Methods: It is a prospective,observational study, conducted at Medicine Department, Mayo Hospital Lahore for 6 months i.e.1stJanuary to 30th June 2018. After the ethical approval, 160 diagnosed cases of chronic hepatitis C of ages18-70 years of either gender were selected by non-probability purposive sampling. Informed writtenconsent was taken. Demographic information such as name, age and gender were recorded. Venous bloodsamples from patients after 10 to 14 hours of fasting were drawn for lipid profiles and sent to pathologylaboratory. All results were expressed as mg/dl. Data were analyzed in SPSS version 22 Results: Out of160 patients in this study, there were 94 males and 66 females. Total cholesterol was lower in 62.5%patients, normal in 33.75% patients and higher in 3.75% patients. Triglycerides levels were low in 66.25%,normal in 33.125%, and high in 0.625% patients. Low density lipoprotein (LDL) levels were low in 82.5%patients, normal in 10% and raised in 7.5% patients. High density lipoprotein (HDL) levels were low in 95%,normal in 4.375% & high in 0.625% patients Conclusions: Low levels of serum lipids including totalcholesterol, triglycerides, LDL and HDL are seen in population suffering from chronic HCV infection.