Abstract
INTRODUCTION: Chromosomal instability may contribute to breast cancer progression and heterogeneity. Gene-expression profiling clustered breast tumors into subclasses IA, predominantly HER2-positive; IB, ER-negative/HER2-negative “basal-like”; IIA, low-grade ER-positive; and IIB, high-grade ER-positive. We hypothesized that chromosomal instability differs among these subclasses, and assessed tumor ploidy and frequency of allelic imbalance.
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