Abstract
BackgroundLipid abnormality pervasively is associated with the risk of type 2 diabetes mellitus. To the best of our knowledge, there is no study that has examined the longitudinal changes in a wide range of serum lipid profiles in prediabetic subjects in association with the risk of developing type 2 diabetes mellitus in the future. This study aimed to identify the patterns of changes in lipid profiles over time in prediabetic patients and to classify these subjects in order to highlight which patients are at high risk for future diabetes.MethodsThis prospective 16-year (2003–2019) cohort study was conducted among 1228 prediabetic subjects. The study subjects were followed, and the changes in their lipid profiles, including triglycerides, cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol, were evaluated. The latent Markov model was used for data analysis.ResultsThe mean (standard deviation) age of subjects was 44.0 (6.8) years, and 73.6% of them were female. The latent Markov model identified two latent states of subjects in terms of changes in lipid profiles: a low tendency to progress diabetes / high tendency to progress diabetes (74, 26%). The latent Markov model showed that the transition probability from a “low tendency to progress diabetic” state to a “high tendency to progress diabetic” state was lower than the transition probability from “high tendency to progress diabetic” state to “low tendency to progress diabetic” state.ConclusionsThe present study showed that more than half of the first-degree relatives of T2DM had approximately normal lipid profiles and that these patients are more inclined to transition from a higher- to a lower-tendency diabetic state. These findings confirm the value of regular screening of first-degree relatives of T2DM. Moreover, preventive intervention strategies are recommended to reduce their risk of developing T2DM.
Highlights
Type 2 diabetes mellitus (T2DM) is a common chronic disease with major morbidities and high mortality rate [1]
Study design and participants The current study was conducted under the framework of the Isfahan Diabetes Prevention Study (IDPS), which was initiated in 2003 among 3483 first-degree relatives (FDRs) from a consecutive sample of patients with T2DM
The IDPS is an ongoing longitudinal study carried out in a cohort of the FDRs of patients with T2DM in Isfahan, which is the largest city in central Iran, to assess the various potential risk factors for diabetes in subjects with a family history of T2DM
Summary
Type 2 diabetes mellitus (T2DM) is a common chronic disease with major morbidities and high mortality rate [1]. It is estimated that 5–10% of subjects with PD will develop T2DM [7]. Lipid abnormality pervasively is associated with the risk of type 2 diabetes mellitus. To the best of our knowledge, there is no study that has examined the longitudinal changes in a wide range of serum lipid profiles in prediabetic subjects in association with the risk of developing type 2 diabetes mellitus in the future. This study aimed to identify the patterns of changes in lipid profiles over time in prediabetic patients and to classify these subjects in order to highlight which patients are at high risk for future diabetes
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