Abstract
The effects of 5-fluorouracil on bacteriophage production in E. coli, strain B, have been studied. In the presence of the fluoropyrimidine the phage yields are less than 0.5% of the control in T2r infection, whereas as much as 8% of the control yield is obtained in T3 infection. The addition of uracil does not affect the inhibition of T2r multiplication, but restores T3 formation to 40–50% of normal. Supplementation with thymidine has little effect on T3, but raises the yield of T2r to more than one fifth of the control. Essentially complete restoration of phage reproduction is observed when both uracil and thymidine are present together with fluorouracil. Orienting experiments with phages TI and T4r are also described.
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