Patterns of care and survival in cancer patients with cognitive impairment

Abstract

8083 Background: Literature on survival patterns of geriatric patients with cancer and cognitive impairment is scant. The existing analects reveal cancer patients with cognitive impairment have twice the mortality of their non-impaired counterparts. The reason for the high mortality rates is unclear. There is an obvious need for clinical research to guide oncologists in the treatment of these patients. Methods: We conducted a retrospective case-control study in geriatric oncology patients aged 70 and older. Patients seen in Moffitt's Senior Adult Oncology Program (SAOP) presenting at initial CGA a MMSE of 24 or less were paired with patients presenting a MMSE of 25 or higher. Patients were matched for tumor type and stage. Baseline criteria were obtained from the SAOP prospective cohort database. Patterns of care and morbidity outcomes (PFS, OS) were obtained from Moffitt Cancer registry. Data were adjusted for baseline ECOG PS, ADL/IADL, CIRS - G and Charlson scores, GDS, age and sex with a Cox regressio...