Abstract
Three stochastic microsensors were developed and used for analysis of HER-2 (a protein from Epidermal Growth Factor Receptor (EGFR) tyrosine kinase family) in whole blood samples. Chitosan I (n = 371 - 744), chitosan II (n = 868 - 1365), and maltodextrin (DE 4–7) were used as modifiers for the design of the new stochastic sensors based on diamond paste. The microsensors proposed can be used for the analysis of HER-2 in the concentration range between 3 fg/mL to 30 ng/mL. The highest sensitivity (1.47 × 107 s−1/mg/mL) was obtained for the microsensor based on chitosan II and diamond paste, while the lower limit of quantification (3 pg/mL) was obtained when the microsensor based on chitosan I and diamond paste was used. HER-2 was reliable determined from whole blood samples with recoveries higher than 93.00%.
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