Pattern recognition in a compartmental model of a CA1 pyramidal neuron

Abstract

Computer simulation of a CA1 hippocampal pyramidal neuron is used to estimate the effects of synaptic and spatio-temporal noise on such a cell's ability to accurately calculate the weighted sum of its inputs, presented in the form of transient patterns of activity. Comparison is made between the pattern recognition capability of the cell in the presence of this noise and that of a noise-free computing unit in an artificial neural network model of a heteroassociative memory. Spatio-temporal noise due to the spatial distribution of synaptic input and quantal variance at each synapse degrade the accuracy of signal integration and consequently reduce pattern recognition performance in the cell. It is shown here that a certain degree of asynchrony in action potential arrival at different synapses, however, can improve signal integration. Signal amplification by voltage-dependent conductances in the dendrites, provided by synaptic NMDA receptors, and sodium and calcium ion channels, also improves integration and pattern recognition. While the biological sources of noise are significant when few patterns are stored in the associative memory of which the cell is a part, when large numbers of patterns are stored the noise from the other stored patterns comes to dominate the pattern recognition process. In this situation, the pattern recognition performance of the pyramidal cell is within a factor of two of that of the computing unit in the artificial neural network model.