Abstract
Pattern of surgical antibiotic prophylaxis in a tertiary care teaching hospital in India
Highlights
Surgical site infection (SSI) is the most common post operative complication and represents a significant burden in terms of patient morbidity and mortality, and cost to health services around the world
All patients with closed fractures (14 cases) received antibiotic prophylaxis, cefotaxime plus gentamicin was prescribed in majority of these cases
Combinations of antibiotics were used in all the surgical departments and 17% patients received three or more drugs together
Summary
Surgical site infection (SSI) is the most common post operative complication and represents a significant burden in terms of patient morbidity and mortality, and cost to health services around the world. Appropriate antibiotic prophylaxis has been shown to be effective in reducing the incidence of surgical site infections. Selection of an appropriate antimicrobial agent (AMA) depends on the pathogen most likely to cause an infection. A single pre operative antibiotic dose is sufficient for operations lasting up to 4.10 In prolonged surgeries, further antibiotic doses may be needed to maintain the drug levels. Re-administration should be considered in the event of prolonged or excessive intraoperative bleeding. Timing of antibiotic prophylaxis is considered optimal if administered within 30 minutes prior to incision.[11] vancomycin or fluoroquinolone antibiotics should be given within 2 hours before the first surgical skin incision
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