Pattern of Renal involvement in Systemic Lupus Erythematosus patients in Sohag University Hospitals

Abstract

Background: Systemic Lupus Erythematosusis asystemic disease characterized by multiple system affection,each system affected has apathognomonic features for lupus affection,renal involvement have variable patterns in SLE and tretment vary accordingly. Objective: The objective of this study is to study pattern of renal involvement in Systemic Lupus Erythematosus patients in Sohag University Hospitals . Materials &Methods:This study was performed on 100 patients with SLE who fulfiled the clinical and laboratory criteria of (Modified american colleague of rheumatology for SLE diagnosis-1997)admitted to Sohag University Hospital and those of outpatients clinic were studied by means of a retrospective review of their records, Patients were analyzed according to their clinical symptoms and laboratory profile which included complete blood counts, serum creatinine and electrolytes, ESR, total proteins, 24 hour urinary proteins, creatinine clearance, anti nuclear factor and anti-DNA. Results of renal biopsy which were performed by light microscopy study were revised.Results: The study revealed that class( 2) were 46 patients (46%) all of them were females.Class (3) were 36 patients (36%), 33 of them were females, 3 patients were males.Class (4) were 14 patients (14%) all of them were females .Class (5) were 4 patients ( 4% ) all of them were females .According to proteinuria between classes of renal biopsy , 24 h urinary protein was > .5 g in all patients of class 5 (100%) .Class (3) and class (4) the same range (about 92%), class 2 about (84%).Conclusion: Our study in Sohag University Hospitals was in 100 patients revealed that roughly number of rural patients equal to urban patients , also revealed that the most common renal biopsy class is the class (2) in our locality and that the most common symptoms associated with renal involvement is arthritis followed by oral ulceration. Anaemia affect most of our patients in Sohag and thrombocytopenia very common between them , our study show that proteinuria increased markedly by increasing grades of renal biopsy with low response to treatment, this may explained by non compliance of our patients to treatment .