Abstract
The prevalence and pattern of specific learning disabilities (LD) in neurologically normal children with extremely low birth weight (ELBW) (<800 g) and average intelligence were compared with full-term children with normal birth weight in a study at the British Columbia Research Institute for Children’s and Women’s Health, University of British Columbia, Vancouver, BC.
Highlights
The prevalence of fragile X syndrome, velocardiofacial syndrome (VCFS), and other cytogenetic abnormalities among 100 children (64 boys) with combined type ADHD and normal intelligence was assessed at the NIMH and Georgetown University Medical Center
In the absence of clinical indications, including developmental delay, physical signs, or positive family history, testing for chromosomal abnormalities, VCFS, or fragile X is not indicated in children with ADHD of normal intelligence
Pediatric Neurology Briefs 2002 and average intelligence were compared with full-term children with normal birth weight in a study at the British Columbia Research Institute for Children's and Women's Health, University of British Columbia, Vancouver, BC
Summary
The prevalence of fragile X syndrome, velocardiofacial syndrome (VCFS), and other cytogenetic abnormalities among 100 children (64 boys) with combined type ADHD and normal intelligence was assessed at the NIMH and Georgetown University Medical Center. Prevalences exceeding 5.5% for chromosomal abnormalities, 3.7% for VCFS, and 3.6% for fragile X full mutations were excluded. In children with ADHD and normal intelligence with no clinical signs and absent family history of chromosome anomalies, testing for cytogenetic abnormalities is not warranted. I Am Acad Child Adolesc Psychiatry July. In the absence of clinical indications, including developmental delay, physical signs, or positive family history, testing for chromosomal abnormalities, VCFS, or fragile X is not indicated in children with ADHD of normal intelligence. (Tercyak KP et al T Am Acad Child Adolesc Psychiatry July 2002;41:799-805). Increased slow activity over frontal areas and decreased fast cortical activity were observed, indicating a different arousal pattern and possible delay in cortical maturation. (El-Sayed E, et al 1 Am Acad Child Adolesc Psychiatry July 2002;41:811-819)
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