Abstract
The inbred marriages are highly acceptable in many populations of human beings but their prevalence and configuration vary depending on ethnicity, religious conviction, learning and socioeconomic circumstances of relevant population. Such social contracts are reported as the most important cause of enhancing the occurrence of the hereditary disorders by recessive autosomal, especially Thalassemia. The challenges of hereditary diseases trouble in the population calls for the progress of anticipation programs. But the implementations of different means require the information about types and prevalence of hereditary diseases and family system in population. This study focuses on inbred marriages and genetic diseases in the general population of Tuman Leghari resident in district D.G. Khan, Punjab, Pakistan. Ethnically the highest positive response was found in Saraiki (other than Baloch) 47.30% than Leghari (32.26%) or Khosa (20.44%). The Saraiki other than Baloch, Khosa and Leghari families were 47.30%, 32.26%, and 20.44% respectively. There was many differences found between the frequency of inbred and out bred marriages of total sample as well as within the ethnic groups, Leghari, and Khosa (X2=10.87 P
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