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Abstract
BackgroundThe French West-Indies rank first for both prostate cancer incidence and mortality rates. Analyzing diagnostic and therapeutic procedures among patients with prostate cancer, using data from a population-based cancer registry, is essential for cancer surveillance and research strategies.MethodsThis retrospective observational cohort study was based on data from the Martinique Cancer Registry. Records of 452 patients diagnosed with prostate cancer in 2013 were retrieved from the registry. Data extracted were: socio-demographic and clinical characteristics, circumstances of diagnosis, PSA level at diagnosis, Gleason score and risk of disease progression. Stage at diagnosis and patterns of care among prostate cancer patients were analyzed.ResultsMean age at diagnosis was 67 ± 8 years; 103 (28.5%) were symptomatic at diagnosis. Digital rectal exam was performed in 406 (93.8%). Clinical stage was available in 385 (85.2%); tumours were localized in 322/385 (83.6%). Overall, 17.9% were at low risk, 36.4% at intermediate and 31.9% at high risk; 13.8% were regional/metastatic cancers. Median PSA level at diagnosis was 8.16 ng/mL (range 1.4–5000 ng/mL). A total of 373 patients (82.5%) received at least one treatment, while 79 (17.5%) had active surveillance or watchful waiting. Among patients treated with more than one therapeutic strategy, the most frequent combination was external radiotherapy with androgen deprivation (n = 102, 22.6%).ConclusionsThis study provides detailed data regarding the quality of diagnosis and management of patients with prostate cancer in Martinique. Providing data on prostate cancer is essential for the development of high-priority public health measures for the Caribbean.
Highlights
The French West-Indies rank first for both prostate cancer incidence and mortality rates
Higher tumor grade is reported in African-Caribbean populations and a higher risk of metastatic progression among black men; studies on prostate cancer (PCa) management are a huge challenge in our region to investigate and explain the observed higher incidence [9,10,11,12,13]
Demographic and diagnostic characteristics In total, 473 new cases of PCa were diagnosed in Martinique in 2013
Summary
The French West-Indies rank first for both prostate cancer incidence and mortality rates. In the Caribbean, the French West-Indies rank first for both PCa incidence and mortality rates, which have been suggested to be partially related to the high prevalence of some gene polymorphisms and environmental endocrine disruptors [6,7,8]. Higher tumor grade is reported in African-Caribbean populations and a higher risk of metastatic progression among black men; studies on PCa management are a huge challenge in our region to investigate and explain the observed higher incidence [9,10,11,12,13]. The MCR is one of the only two French population-based cancer registries (PBCR) among the 30 nations and territories of the Caribbean [14]. For men diagnosed during this period, 5-year survival was 97.5% with a world-standardized mortality rate of 23.5 per 100,000 [17]
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