Abstract
Klebsiella Pneumoniae is one of the most common causes of nosocomial respiratory tract infections all over the world. Unfortunately, it is developing resistance to many antibiotics. This study was carried out in a teaching hospital for determining the prevalence and pattern of antibiotic sensitivity among Klebsiella pneumoniae isolated from sputum samples of hospital acquired respiratory tract infection. A total of 154 samples were included in the present study. Klebsiella Pneumoniae were isolated in (21.52%) samples and identified by standard microbiological techniques. Antibiotic susceptibility testing was done by the Kirby-Bauer disc diffusion method and interpreted as per CLSI guidelines. Isolated strains were sensitive to Amikacin (70%) Levofloxacin (70%) Gentamicin (65%) Chloramphenicol (65%) and resistant to Ampicillin (98.72%) Co-trimoxazole (87.5%) Ceftriaxone (85%) Tigecycline (85%) Tobramycin (85%). This study may help to formulate local antibiotic policy as a part of rational antibiotic therapy for hospitals; this may reduce the development of multi-drug resistance.
Highlights
Klebsiella Pneumoniae, a gram-negative opportunistic bacterium, ubiquitously present and isolated worldwide causing nosocomial infections. 1 it develops resistance to a various class of antibiotics including betalactam group
Gender vise 16.67% (12/72)females and 25.59% (22/86) males were positive for Klebsiella Pneumoniae isolation
The age group above 60 years shows the highest isolation of Klebsiella Pneumoniae Among 19 females 04 (33.33%)were Klebsiella Pneumoniae positive & out of 25 males 09 (40.91%) were positive for Klebsiella Pneumoniae
Summary
Klebsiella Pneumoniae, a gram-negative opportunistic bacterium, ubiquitously present and isolated worldwide causing nosocomial infections. 1 it develops resistance to a various class of antibiotics including betalactam group. Klebsiella Pneumoniae, a gram-negative opportunistic bacterium, ubiquitously present and isolated worldwide causing nosocomial infections. Indiscriminate prescription and overuse of beta-lactam group of antibiotics are responsible for drug resistance. 2 Multi-drug resistant (MDR) Klebsiella Pneumoniae isolates were defined by non-susceptibility to at least one agent in three or more antibiotic categories.[3]. Klebsiella Pneumoniae is a gram-negative, encapsulated, non-motile, lactose fermenting, facultative anaerobe belonging to the Enterobacteriaceae family. This was isolated by Friedlander from the lungs of patients who died of Pneumonia. Klebsiella Pneumoniae had been identified as a causative agent in nosocomial pneumonia (7 to 14%), septicemia (4 to 15%), wound infections (2 to 4%) and neonatal pneumonia (3 to 30%). Klebsiella Pneumoniae had been identified as a causative agent in nosocomial pneumonia (7 to 14%), septicemia (4 to 15%), wound infections (2 to 4%) and neonatal pneumonia (3 to 30%). 4
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