PATTERN OF ACTIVE BLOOD DONORS DONATING FOR MORE THAN 10 YEARS BASED ON THE RESULTS OF LABORATORY, MORPHOLOGIC, BIOCHEMICAL AND BIOPHYSICAL TESTS OF PERIPHERAL BLOOD

Abstract

Introduction: In spite of the lately increasing number of scientific research programs on donor blood storage, integrated solution of this problem remains a challenging open issue. The aim: upon the study of laboratory, morphologic, biochemical and biophysical properties of donor blood erythrocytes, determine pathogenesis of abnormalities in erythrocytes of blood donors depending and increase effectiveness of early diagnostics and prevention of the above changes for donors' health protection. Materials and methods: 215 blood donors (112 men and 103 women) were examined, among which 55 were active donors (29 men and 26 women) donating on regular basis, no less than 3 times a year and 160 first-time registered donors (83 men and 77 women). First-time registered donors made the control group of our research. The following methods were used: general blood tests, blood chemistry, radioimmune and enzyme-immunoassay, statistic methods. Results: Results of the performed laboratory, morphologic, biochemical and biophysical tests: erythrocyte index determination, reticulocyte count, red blood cell distribution width, optical transmission of erythrocytes, test for aggregation and penetrability of erythrocyte membranes, effectiveness of erythropoiesis value determination in regular donor's and first-time donors erythrocytes demonstrated that the examined person making the group of donors are practically healthy people whose test results are within normal limits for their age group. Conclusions: In order to preserve health of donors and ensure quality of blood components received at the time of donation, thorough checkup of donors, including, apart from the main and biochemical peripheral venous blood parameters, morphologic, biophysical and rheological parameters of erythrocytes is highly recommended before donation.