Abstract
ABSTRACTPurpose: To assess pattern electroretinogram (PERG) changes in patients with established or suspected primary open angle glaucoma (POAG).Materials and methods: Transient PERG using LV Prasad eye electrodes were performed in 76 normal, 32 glaucomatous and 22 glaucoma suspect eyes. The P50 amplitude, N95 amplitude and P50 latency were analyzed. The results were further analyzed with receiver operating characteristic (ROC) curves and discriminant function analysis (DFA).Results: The P50 and N95 amplitude of the POAG and glaucoma suspect groups were significantly reduced. There was significant shortening in the P50 latency in the POAG and glaucoma suspect groups. DFA using the P50 amplitude, N95 amplitude and P50 latency waveform parameters showed a sensitivity and specificity of 76.67 and 88.57% respectively.Conclusion: Pattern ERG demonstrated significant changes in POAG patients and suspects. ROC curves for the three wave parameters demonstrated that N95 amplitude was the better indicator for diagnosis of POAG when used individually.How to cite this article: Ganekal S, Dorairaj S, Jhanji V. Pattern Electroretinography Changes in Patients with Established or Suspected Primary Open Angle Glaucoma. J Current Glau Prac 2013;7(2):39-42.
Highlights
IntroductionThe pattern electroretinogram (PERG) is a retinal biopotential evoked by a temporally modulated patterned stimulus (e.g. checkerboard or grating) of constant mean luminance
The pattern electroretinogram (PERG) is a retinal biopotential evoked by a temporally modulated patterned stimulus of constant mean luminance
receiver operating characteristic (ROC) curves for the three wave parameters demonstrated that N95 amplitude was the better indicator for diagnosis of primary open angle glaucoma (POAG) when used individually
Summary
The pattern electroretinogram (PERG) is a retinal biopotential evoked by a temporally modulated patterned stimulus (e.g. checkerboard or grating) of constant mean luminance. Pattern ERG allows both a measure of central retinal function, and, in relation to its origins, an evaluation of retinal ganglion cell function and an evaluation of macular dysfunction.[1]. There are evidences to suggest that large diameter ganglion cells which produce PERG are affected earlier than small ganglion cells in the evolution of glaucoma.[2,3] PERG changes can help detecting early glaucomatous damage. PERG recorded from glaucomatous eyes that had no field defect within the retinal area covered by the PERG stimulus, a pathological PERG were recorded in approximately 71% of such eyes.[4] Serial PERG’s can have a place in management of primary open angle glaucoma (POAG) patients and glaucoma suspects.[5]
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