Abstract
BackgroundWeaning from mechanical ventilation is associated with the presence of asynchronies between the patient and the ventilator. The main objective of the present study was to demonstrate a decrease in the total number of patient-ventilator asynchronies in invasively ventilated patients for whom difficulty in weaning is expected by comparing neurally adjusted ventilatory assist (NAVA) and pressure support ventilation (PSV) ventilatory modes.MethodsWe performed a prospective, non-randomized, non-interventional, single-center study. Thirty patients were included in the study. Each patient included in the study benefited in an unpredictable way from both modes of ventilation, NAVA or PSV. Patients were successively ventilated for 23 h in NAVA or in PSV, and then they were ventilated for another 23 h in the other mode. Demographic, biological and ventilatory data were collected during this period. The two modes of ventilatory support were compared using the non-parametric Wilcoxon test after checking for normal distribution by the Kolmogorov–Smirnov test. The groups were compared using the chi-square test.ResultsThe median level of support was 12.5 cmH2O (4–20 cmH2O) in PSV and 0.8 cmH2O/μvolts (0.2–3 cmH2O/μvolts) in NAVA. The total number of asynchronies per minute in NAVA was lower than that in PSV (0.46 vs 1, p < 0.001). The asynchrony index was also reduced in NAVA compared with PSV (1.73 vs 3.36, p < 0.001). In NAVA, the percentage of ineffective efforts (0.77 vs 0.94, p = 0.036) and the percentage of auto-triggering were lower compared with PSV (0.19 vs 0.71, p = 0.038). However, there was a higher percentage of double triggering in NAVA compared with PSV (0.76 vs 0.71, p = 0.046).ConclusionThe total number of asynchronies in NAVA is lower than that in PSV. This finding reflects improved patient-ventilator interaction in NAVA compared with the PSV mode, which is consistent with previous studies. Our study is the first to analyze patient-ventilator asynchronies in NAVA and PSV on such an important duration. The decrease in the number of asynchronies in NAVA is due to reduced ineffective efforts and auto-triggering.
Highlights
Weaning from mechanical ventilation is associated with the presence of asynchronies between the patient and the ventilator
Population A total of 30 patients who were invasively ventilated in pressure support ventilation (PSV), without sedation, and had risk factors for difficult weaning were included (Table 1)
Twenty-four patients, which represented 80 % of our population, began the study with recording in the PSV mode, which is the most commonly used in the unit
Summary
Weaning from mechanical ventilation is associated with the presence of asynchronies between the patient and the ventilator. 25 % of patients who have invasive ventilation have difficulty in weaning from mechanical ventilation This is defined as failure of spontaneous breathing or resumption of mechanical ventilation within 48 h of removal [2]. For these patients, the time spent in weaning from mechanical ventilation can account for up to half of the total duration of invasive ventilation [3]. The time spent in weaning from mechanical ventilation can account for up to half of the total duration of invasive ventilation [3] Most of these patients have chronic respiratory disease [4] (either chronic obstructive pulmonary disease or chronic respiratory failure), heart disease [3], or are undergoing long-term mechanical ventilation [2]
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